Drug brain distribution following intranasal administration of Huperzine A in situ gel in rats
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Accumulation of manganese in rat brain following intranasal administration.
Manganese chloride (50-800 micrograms) was injected unilaterally into the right nostril of rats and its accumulation in the central nervous system (CNS) was monitored. Brain manganese levels were elevated in a dose-dependent, time-dependent, and tissue-dependent manner. Elevated levels of manganese were detected in the right olfactory bulb and olfactory tubercle within 12 hr after instillation ...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2007
ISSN: 1671-4083,1745-7254
DOI: 10.1111/j.1745-7254.2007.00486.x